Publications | Ernest Y. Lee, MD, PhD

Lee, E.Y., Chan, L., Wang, H., Lieng J., Hung, M., Srinivasan, Y., Wang, J., Waschek, J., Ferguson, A.L., Lee, K.F., Yount, N.Y., Yeaman, M.R., Wong, G.C.L. PACAP is a pathogen-inducible resident antimicrobial neuropeptide affording rapid and contextual molecular host defense of the brain. Proc Natl Acad Sci USA 118(1) e1917623117, 2021.

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Bloom, M.B., Noorzad, A., Lin, C., Little, M., Lee, E.Y., Torbati, S. Standing electric scooter injuries: Impact on a community. The American Journal of Surgery 221(1): 227-232, 2021.

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Lee, E.Y., Arzeno, J., Ni, C., Holland, V. Ocular lichen planus treated with lifitegrast. In press International Journal of Dermatology, 2020.

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Lee, E.Y., Maloney, N.J., Cheng, K., Bach, D.Q. Machine learning for precision dermatology: Advances, opportunities, and outlook. In press, Journal of the American Academy of Dermatology, 2020.

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Lee, E.Y., Srinivasan, Y., de Anda, J., Nicastro, L.K., Tükel, Ç., Wong, G.C.L. Functional reciprocity of amyloids and antimicrobial peptides: Rethinking the role of supramolecular assembly in host defense, immune activation, and inflammation. In Frontiers In Immunology 11: 1629, 2020.

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Yount, N.Y., Weaver, D.C., de Anda, J., Lee, E.Y., Lee, M.W., Wong, G.C.L., Yeaman, M.R. Discovery of Novel Type II Bacteriocins Using a New High-Dimensional Bioinformatic Algorithm. In Frontiers In Immunology 11: 1873, 2020.

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Lee, E.Y., Chan, L., Wang, H., Lieng J., Hung, M., Srinivasan, Y., Wang, J., Waschek, J., Ferguson, A.L., Lee, K.F., Yount, N.Y., Yeaman, M.R., Wong, G.C.L. Resident neuropeptide PACAP mediates potent cell-free infection defense in tissues. In Journal of Investigative Dermatology 140(7): S40, 2020.

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Fang, J., Liu, Y.T., Lee, E.Y., Yadav, K. Telehealth Solutions for In-hospital Communication with Patients Under Isolation During COVID-19. In Western Journal of Emergency Medicine 21(4): 801-806, 2020.

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Dishman, A.F., Lee, M.W., de Anda, J., Lee, E.Y., He, J., Huppler, A.R., Wong, G.C.L., Volkman, B.F. Switchable membrane remodeling and antifungal defense by metamorphic chemokine XCL1. In ACS Infectious Diseases, 6(5): 1204-1213, 2020.

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Maloney, N.J., Zhao, J., Tegtmeyer, K., Lee, E.Y., Cheng, K.. Off-label studies on apremilast in dermatology: a review. In Journal of Dermatological Treatment 31(2): 131-140, 2020.

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Bloom, M.B., Johnson, J., Volod, O., Lee, E.Y., White, T., Margulies, D.R. Improved prediction of HIT in the SICU using an improved model of the Warkentin 4-T system: 3-T. In The American Journal of Surgery 219(1): 54-57, 2020.

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Lee, E.Y., Kulkarni, R.P. Circulating biomarkers predictive of tumor response to cancer immunotherapy. In Expert Review of Molecular Diagnostics 19(10): 895-904, 2019.

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Lee, E.Y., Zhang, C., Di Domizio, J., Takahashi, T., Curk, T., Dobnikar, J., Gallo, R.L., Gilliet, M., Ren, P., Wong, G.C.L. LL37 antimicrobial peptides amplify inflammation in psoriasis by assembling into protofibril scaffolds that present ordered nucleic acids to TLR9 and TLR3. In Journal of Psoriasis and Psoriatic Arthritis 4(3): 159-160, 2019.

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Lee, E.Y., Leforestier, A., Di Domizio, J., Curk, T., Abbaspour, L., Berezhnoy, N., Fazli, H., Nordenskiold, L., Dobnikar, J., Gilliet, M., Wong, G.C.L. NETs generate structured antimicrobial peptide-nucleosome immune complexes with inter-DNA spacings optimal for TLR9 activation. In Journal of Investigative Dermatology 139(5): S3, 2019.

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Silvestre-Roig, C.#, Braster, Q.#, Wichapong, K., Lee, E.Y., Teulon, J.M., Berrebeh, N., Winter, J., Adrover, J.M., Santos, G.S., Froese, A., Lemnitzer, P., Ortega-Gomez, A., Chevre, R., Marschner, J., Schumski, A., Winter, C., Perez-Olivares, L., Pan, C., Paulin, N., Schoufour, T., Hartwig, H., Gonzalez-Ramos, S., Kamp, F., Megens, R.T.A., Mowen, K.A., Gunzer, M., Maegdefessel, L., Hackeng, T., Lutgens, E., Daemen, M., von Blume, J., Anders, H.-J., Nikolaev, V.O., Pellequer, J.-L., Weber, C., Hidalgo, A., Nicolaes, G.A.F., Wong, G.C.L., Soehnlein, O. Externalized histone H4 orchestrates chronic inflammation by inducing lytic cell death. In Nature 569(7755): 236-240, 2019.

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Lande, R., Lee, E.Y., Palazzo, R., Marinari, B., Pietraforte, I., Santos, G.S., Mattenberger, Y., Spadaro, F., Stefanantoni, K., Iannace, N., Dufour, A.M., Falchi, M., Bianco, M., Botti, E., Bianchi, L., Alvarez, M., Riccieri, V., Truchetet, M.-E., Wong, G.C.L., Chizzolini, C., Frasca, L. CXCL4 assembles DNA into liquid crystalline complexes to amplify TLR9-mediated interferon-α production in systemic sclerosis. In Nature Communications 10(1): 1731, 2019.

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Lee, E.Y.#, Zhang, C.#, Di Domizio, J., Jin, F., Connell, W., Hung, M., Malkoff, N., Veksler, V., Gilliet, M., Ren, P., Wong, G.C.L. Helical antimicrobial peptides assemble into protofibril scaffolds that present ordered dsDNA to TLR9. In Nature Communications 10(1): 1012, 2019.

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Yount, N.Y., Weaver, D.C., Lee, E.Y., Lee, M.W., Wang, H., Chan, L.C., Wong, G.C.L., Yeaman, M.R. A Unifying Structural Signature of Eukaryotic ⍺-helical Host Defense Peptides. In Proc Natl Acad Sci USA 116(14): 6944-6953, 2019.

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Lee, E.Y., Lee, M.W., Wong, G.C.L. Modulation of toll-like receptor signaling by antimicrobial peptides. In Seminars in Cell & Developmental Biology 88: 173-184, 2019.

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Lee, M.W., Lee, E.Y., Ferguson, A.L., Wong, G.C.L. Machine Learning Antimicrobial Peptide Sequences: Some Surprising Variations on the Theme of Amphiphilic Assembly. In Current Opinion in Colloid and Interface Science 38: 204-213, 2018.

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Lee, M.W., Lee, E.Y., Wong, G.C.L. What can pleiotropic proteins in innate immunity teach us about bioconjugation and molecular design?. In Bioconjugate Chemistry 29 (7): 2127-2139, 2018.

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Lee, E.Y., Wong, G.C.L., Ferguson, A.L. Machine learning-enabled discovery and design of membrane-active peptides. In Bioorganic & medicinal chemistry 26(10): 2708-2718, 2018.

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Takahashi, T., Kulkarni, N.N., Lee, E.Y., Zhang, L-J., Wong, G.C.L., Aiba, S., Gallo, R.L. Discovery of a receptor-dependent step in cathelicidin activation of inflammation identifies a novel therapeutic target for psoriasis and rosacea. In Journal of Investigative Dermatology 138(5): S151, 2018.

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Lee, E.Y.. Discovery and Design of Multifunctional Membrane-Active and Immunomodulatory Peptides and Proteins. In University of California, Los Angeles, ProQuest Dissertations Publishing: 10785702, 2018.

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Lee, C.K.#, De Anda, J.#, Baker, A.E., Bennett, R.R., Luo, Y., Lee, E.Y., Keefe, J.A., Helali, J.S., Ma, J., Zhao, K., Golestanian, R., O‘Toole, G.A., Wong, G.C.L. Multigenerational Memory and Adaptive Adhesion in Early Bacterial Biofilm Communities. In Proc Natl Acad Sci USA 115(17): 4471-4476, 2018.

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Takahashi, T., Kulkarni, N.N., Lee, E.Y., Zhang, L-J., Wong, G.C.L., Gallo, R.L. Cathelicidin promotes inflammation by enabling binding of self-RNA to cell surface scavenger receptors. In Scientific Reports 8(1):4032, 2018.

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Lee, M.W., Lee, E.Y., Lai, G.H. Kennedy, N.W., Posey, A.E., Xian, W., Ferguson A.L., Hill, R.B., Wong, G.C.L. Molecular Motor Dnm1 Synergistically Induces Membrane Curvature To Facilitate Mitochondrial Fission. In ACS central science 3(11): 1156-1167, 2017.

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Lee, E.Y., Lee, M.W., Fulan, B.M., Ferguson, A.L., Wong, G.C.L. What can machine learning do for antimicrobial peptides, and what can antimicrobial peptides do for machine learning?. In Interface focus 7(6): 20160153, 2017.

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Lee, E.Y., Takahashi, T., Curk, T., Dobnikar, J., Gallo, R.L., Wong, G.C.L. Crystallinity of Double-Stranded RNA-Antimicrobial Peptide Complexes Modulates Toll-Like Receptor 3-Mediated Inflammation. In ACS Nano 11(12): 12145-12155, 2017.

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De Anda, J.#, Lee, E.Y.# (co-first author), Lee, C.K.#, Bennett, R.R., Ji, X., Soltani, S., Harrison, M.C., Baker, A.E., Luo, Y., Chou, T., O’Toole, G.A., Armani, A.M., Golestanian, R., Wong, G.C.L. High-Speed "4D" Computational Microscopy of Bacterial Surface Motility. In ACS Nano 11(9): 9340-9351, 2017.

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Stolzenberg, E., Berry, D., Yang, D., Lee, E.Y., Kroemer, A., Kaufman, S., Wong, G.C.L., Oppenheim, J., Sen, S., Fishbein, T., Bax, A., Harris, B., Barbut, D., Zasloff, M.A. A Role for Neuronal Alpha-Synuclein in Gastrointestinal Immunity. In Journal of Innate Immunity 9(5): 456-463, 2017.

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Lee, E.Y., Takahashi, T., Curk, T., Dobnikar, J., Gallo, R.L., Wong, G.C.L. Liquid crystalline ordering of antimicrobial peptide-RNA complexes controls TLR3 activation. In Journal of Investigative Dermatology 137(5): S12, 2017.

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Kaplan, A.#, Lee, M.W.#, Wolf, A.J., Limon-Tello, J., Becker, C.A., Ding, M., Murali, R., Lee, E.Y., Liu, G.Y., Wong, G.C.L., Underhill, D.M. Direct Antimicrobial Activity of IFN-β. In Journal of immunology (Baltimore, Md. : 1950) 198(10): 4036-4045, 2017.

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Tursi, S.A., Lee, E.Y., Medeiros, N.J., Lee, M.H., Butter B., Galluccci S., Wilson, R.P., Wong, G.C.L., Tükel, Ç. Bacterial amyloid curli acts as a carrier for DNA to elicit an autoimmune response via TLR2 and TLR9. In PLoS Pathogens 13(4): e1006315, 2017.

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Realegeno, S., Kelly-Scumpia, K.M., Dang, A.T., Lu, J., Teles, R., Liu, P.T., Schenk, M., Lee, E.Y., Schmidt, N.W., Wong, G.C.L., Sarno, E.N., Rea, T.H., Ochoa, M.T., Pellegrini, M., Modlin, R.L. S100A12 Is Part of the Antimicrobial Network against Mycobacterium leprae in Human Macrophages. In PLoS Pathogens 12(6): e1005705, 2016.

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Lee, E.Y., Fulan, B.M., Wong, G.C.L., Ferguson, A.L. Mapping membrane activity in undiscovered peptide sequence space using machine learning. In Proc Natl Acad Sci USA 113(48): 13588-13593, 2016.

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Lee, E.Y., Lee, C.K., Schmidt, N.W., Jin, F., Lande, R., Curk, T., Frenkel, D., Dobnikar, J., Gilliet, M., Wong, G.C.L. A review of immune amplification via ligand clustering by self-assembled liquid-crystalline DNA complexes. In Advances in colloid and interface science 232: 17-24, 2016.

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Sankhagowit, S., Lee, E.Y., Wong, G.C.L., Malmstadt, N. Oxidation of Membrane Curvature-Regulating Phosphatidylethanolamine Lipid Results in Formation of Bilayer and Cubic Structures. In Langmuir 32(10): 2450-2457, 2016.

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