Physics Meets Biomedicine

I combine biophysics and computational biology to explore problems at the interface of infectious and autoimmune diseases. I am working on elucidating molecular rules underlying the membrane-remodeling and immunomodulatory activities of multifunctional peptides and proteins.

Publications

More Publications

. Machine learning for personalized dermatology: Advances, opportunities, and outlook. Submitted, 2019.

. Electric Scooters: Impact on a Community. Submitted, 2019.

. The neuropeptide PACAP is antimicrobial and potently induced in the brain during infection. Submitted, 2019.

. Circulating biomarkers predictive of tumor response to cancer immunotherapy. In press, Expert Review of Molecular Diagnostics, 2019.

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. Improved prediction of HIT in the SICU using an improved model of the Warkentin 4-T system: 3-T. In press, The American Journal of Surgery, 2019.

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. LL37 antimicrobial peptides amplify inflammation in psoriasis by assembling into protofibril scaffolds that present ordered nucleic acids to TLR9 and TLR3. In Journal of Psoriasis and Psoriatic Arthritis 4(3): 159-160, 2019.

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Projects

Design Rules for Immunomodulation by Host-Defense Peptides

How do antimicrobial peptides modulate Toll-like receptor signaling?

Membrane-Active Peptides and Proteins

Machine-learning enabled discovery and design of membrane-active peptides and proteins.

Multifunctional Peptides and Proteins

How does nature conjugate multiple functions into a single protein domain, including receptor-binding and membrane activity?

Autoimmune Diseases and Chronic Inflammation

What is the mechanistic basis of autoimmunity?

Awards and Honors

Year Award
2019 Elected as Junior Member to AΩA, David Geffen School of Medicine, UCLA
2019 National Psoriasis Foundation Travel Grant, National Psoriasis Foundation
2019 Society for Investigative Dermatology Post-Doctoral Retreat Trainee Scholarship, Society of Investigative Dermatology
2019 Keystone Symposia Trainee Scholarship, Keystone Symposia on Molecular and Cellular Biology
2019 Edward K. Rice Outstanding Doctoral Student Award, UCLA Samueli School of Engineering
2018 Department of Bioengineering Outstanding Ph.D. Student Award, UCLA Samueli School of Engineering
2017 Peptide Therapeutics Foundation Travel Grant, Peptide Therapeutics Foundation
2017 NIH NIAMS T32 Dermatology Scientist Training Program Grant (T32AR071307), UCLA
2017 National Psoriasis Foundation Travel Grant, National Psoriasis Foundation
2017 National Psoriasis Foundation Early Career Research Grant, National Psoriasis Foundation
2017 Doctoral Student Travel Grant, UCLA
2017 Department of Bioengineering Graduate Student Supplemental Fellowship, UCLA Samueli School of Engineering
2015 NIH NIGMS T32 Systems and Integrative Biology Training Program Grant (T32GM008185), UCLA
2015 Hertz Foundation Graduate Fellowship Finalist, The Fannie and John Hertz Foundation
2014 NIH NIGMS T32 Systems and Integrative Biology Training Program Grant (T32GM008185), UCLA
2013 3rd Prize, Inventathon, UCLA Business of Science Center
2012 NIH NIGMS T32 Medical Scientist Training Program Grant (T32GM008042), David Geffen School of Medicine, UCLA
2011 Øistein and Rita A. Skjellum Summer Undergraduate Research Fellowship, California Institiute of Technology
2010 Rose Hills Foundation Scholarship, California Institiute of Technology
2008 Spence Reese Scholarship in Medicine, Boys & Girls Clubs of Greater San Diego

Recent & Upcoming Talks

Host defense peptides amplify TLR9-mediated inflammation in autoimmune diseases by scaffolding dsDNA into spatially-periodic nanocrystals
Mar 13, 2019 5:00 PM
NETs generate immune complexes to amplify TLR9-based inflammation in psoriasis
Jun 23, 2018 10:00 AM
Design Rules for Immunomodulation by Host-Defense Peptides
Mar 6, 2018 3:30 PM
Machine learning and membrane remodeling activity
Jan 10, 2018 10:45 AM

Contact

  • ernest.lee@ucla.edu
  • 4121 Engineering V, UCLA, Los Angeles, California, 90095, USA
  • Email for appointment