Physics Meets Biomedicine

I combine biophysics and computational biology to explore problems at the interface of infectious and autoimmune diseases. I am working on elucidating molecular rules underlying the membrane-remodeling and immunomodulatory activities of multifunctional peptides and proteins.

Publications

More Publications

. NETs generate structured antimicrobial peptide-nucleosome immune complexes with inter-DNA spacings optimal for TLR9 activation. In Journal of Investigative Dermatology 139(5): S3, 2019.

PDF Source Document

. Externalized histone H4 orchestrates chronic inflammation by inducing lytic cell death. In Nature 569: 236-240, 2019.

PDF Source Document

. CXCL4 assembles DNA into liquid crystalline complexes to amplify TLR9-mediated interferon-α production in systemic sclerosis. In Nature Communications 10(1): 1731, 2019.

PDF Source Document

. Helical antimicrobial peptides assemble into protofibril scaffolds that present ordered dsDNA to TLR9. In Nature Communications 10(1): 1012, 2019.

PDF Source Document

. A Unifying Structural Signature of Eukaryotic ⍺-helical Host Defense Peptides. In Proc Natl Acad Sci USA 116(14): 6944-6953, 2019.

PDF Source Document

. Off-label studies on apremilast in dermatology: a review. In Journal of Dermatological Treatment 9: 1-10, 2019.

PDF Source Document

Projects

Design Rules for Immunomodulation by Host-Defense Peptides

How do antimicrobial peptides modulate Toll-like receptor signaling?

Membrane-Active Peptides and Proteins

Machine-learning enabled discovery and design of membrane-active peptides and proteins.

Multifunctional Peptides and Proteins

How does nature conjugate multiple functions into a single protein domain, including receptor-binding and membrane activity?

Autoimmune Diseases and Chronic Inflammation

What is the mechanistic basis of autoimmunity?

Recent & Upcoming Talks

Host defense peptides amplify TLR9-mediated inflammation in autoimmune diseases by scaffolding dsDNA into spatially-periodic nanocrystals
Mar 13, 2019 5:00 PM
NETs generate immune complexes to amplify TLR9-based inflammation in psoriasis
Jun 23, 2018 10:00 AM
Design Rules for Immunomodulation by Host-Defense Peptides
Mar 6, 2018 3:30 PM
Machine learning and membrane remodeling activity
Jan 10, 2018 10:45 AM

Recent Posts

Welcome to my new website!

CONTINUE READING

Contact

  • ernest.lee@ucla.edu
  • 4121 Engineering V, UCLA, Los Angeles, California, 90095, USA
  • Email for appointment