Physics Meets Biomedicine

I combine biophysics and computational biology to explore problems at the interface of infectious and autoimmune diseases. I am working on elucidating molecular rules underlying the membrane-remodeling and immunomodulatory activities of multifunctional peptides and proteins.

Publications

More Publications

. What can pleiotropic proteins in innate immunity teach us about bioconjugation and molecular design?. In Bioconjugate Chemistry: (2018), 2018.

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. Machine learning-enabled discovery and design of membrane-active peptides.. In Bioorganic & medicinal chemistry 26(10): 2708-2718 (2018), 2018.

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. 886 Discovery of a receptor-dependent step in cathelicidin activation of inflammation identifies a novel therapeutic target for psoriasis and rosacea. In Journal of Investigative Dermatology 138(5): S151 (2018), 2018.

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. Discovery and Design of Multifunctional Membrane-Active and Immunomodulatory Peptides and Proteins.. In University of California, Los Angeles, ProQuest Dissertations Publishing: 10785702 (2018), 2018.

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. Multigenerational Memory and Adaptive Adhesion in Early Bacterial Biofilm Communities.. In Proc Natl Acad Sci USA 115(17): 4471-4476 (2018), 2018.

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Projects

Design Rules for Immunomodulation by Host-Defense Peptides

How do antimicrobial peptides modulate Toll-like receptor signaling?

Membrane-Active Peptides and Proteins

Machine-learning enabled discovery and design of membrane-active peptides and proteins.

Multifunctional Peptides and Proteins

How does nature conjugate multiple functions into a single protein domain, including receptor-binding and membrane activity?

Autoimmune Diseases and Chronic Inflammation

What is the mechanistic basis of autoimmunity?

Recent & Upcoming Talks

NETs generate immune complexes to amplify TLR9-based inflammation in psoriasis
Jun 23, 2018 10:00 AM
Design Rules for Immunomodulation by Host-Defense Peptides
Mar 6, 2018 3:30 PM
Machine learning and membrane remodeling activity
Jan 10, 2018 10:45 AM

Recent Posts

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Contact

  • ernest.lee@ucla.edu
  • 4121 Engineering V, UCLA, Los Angeles, California, 90095, USA
  • Email for appointment